Cubn^tm1Sarg
Targeted Allele Detail

Summary

• Symbol: Cubn^tm1Sarg
• Name: cubilin; targeted mutation 1, Scott Argraves
• MGI ID: MGI:3707335
• Synonyms: Cubn^{delexon1-6;EGFP}
• Gene: Cubn Location: Chr2:13281149-13496624 bp, - strand Genetic Position: Chr2, 9.86 cM
• Alliance: Cubn^tm1Sarg page

Cubn^tm1Sarg/Cubn^tm1Sarg embryos display growth retardation at 8-8.5dpc

Show the 4 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:119685
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The promoter-less EGFP and floxed neo cassette were inserted into exon 1, 33 bp upstream of the ATG and 16 bp downstream from the proximal transcription initiation site. Homologous recombination resulted in the loss of most of exon 1 and all of exons 2-6. (J:119685)

Expression

In Mice Carrying this Mutation:	12 assay results
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cubn Mutation: 160 strains or lines available

References

• Original: J:119685 Smith BT, et al., Targeted disruption of cubilin reveals essential developmental roles in the structure and function of endoderm and in somite formation. BMC Dev Biol. 2006;6:30
• All: 2 reference(s)