Ift57^tm1Dwni
Targeted Allele Detail

Summary

• Symbol: Ift57^tm1Dwni
• Name: intraflagellar transport 57; targeted mutation 1, Donald W Nicholson
• MGI ID: MGI:3707373
• Synonyms: Hippi -
• Gene: Ift57 Location: Chr16:49519657-49585489 bp, + strand Genetic Position: Chr16, 31.08 cM, cytoband B5
• Alliance: Ift57^tm1Dwni page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:119664
• Parent Cell Line: mEMS128 (ES Cell)
• Strain of Origin: 129S1/SvImJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1, intron A and part of exon 2 are replaced by a neo cassette. Western blot analysis of E9.5 embryos with an anti-Ift57 antibody confirmed the absence of protein expression. (J:119664)

Expression

In Mice Carrying this Mutation:	30 assay results
In Structures Affected by this Mutation:	12 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ift57 Mutation: 24 strains or lines available

References

• Original: J:119664 Houde C, et al., Hippi is essential for node cilia assembly and Sonic hedgehog signaling. Dev Biol. 2006 Dec 15;300(2):523-33
• All: 1 reference(s)