Tg(Tcra,Tcrb)24Efro
Transgene Detail

Summary

• Symbol: Tg(Tcra,Tcrb)24Efro
• Name: transgene insertion 24, Edward F Rosloniec
• MGI ID: MGI:3707414
• Synonyms: qCII24
• Transgene: Tg(Tcra,Tcrb)24Efro Location: unknown
• Alliance: Tg(Tcra,Tcrb)24Efro page

Transgene origin

• Strain of Origin: (C57BL/6 x C3H)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Tcra,Tcrb)24Efro expresses 2 genes
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Tcra (MGI:98553)
  mouse	Tcrb (MGI:98578)

• Mutation details: Transgenic constructs containing the mouse alpha and beta chain of the T cell receptor recognizing both bovine and mouse type II collagen (260-267) were cloned from the Tcra-V11.1,Tcra-J(J17) and Tcrb-V8.3,Tcrb-D(D1),Tcrb-J(J1.4) expressing I-Aq-restricted T cell hybridoma qCII85.33. Line 24 was established. The transgenic T cell receptor is expressed on >90% of CD4+ T cells in the spleen and lymph nodes. >90% of alphabeta+ T cells in the thymus. (J:104243)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:104243 Brand DD, et al., Detection of early changes in autoimmune T cell phenotype and function following intravenous administration of type II collagen in a TCR-transgenic model. J Immunol. 2002 Jan 1;168(1):490-8
• All: 5 reference(s)