Rad51c^tm1Sks
Targeted Allele Detail

Summary

• Symbol: Rad51c^tm1Sks
• Name: RAD51 paralog C; targeted mutation 1, Shyam K Sharan
• MGI ID: MGI:3707422
• Synonyms: Rad51c^neo
• Gene: Rad51c Location: Chr11:87267471-87295780 bp, - strand Genetic Position: Chr11, 52.08 cM
• Alliance: Rad51c^tm1Sks page

Testes abnormalities in Rad51c^tm1Sks/Rad51c^tm1.1Sks mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:119835
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, Hypomorph)
• Mutation: Insertion
• Mutation details: A floxed neo cassette is inserted between exon 1 and 2 with the addition of a loxP site 3' of exon 3 creating a hypomorphic allele. Aberrant splicing products were confirmed by RT-PCR and decreased protein production was confirmed by quantification of a western blots on mice testicular tissue. (J:119835)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	8 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Rad51c^tm1Sks

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rad51c Mutation: 24 strains or lines available

References

• Original: J:119835 Kuznetsov S, et al., RAD51C deficiency in mice results in early prophase I arrest in males and sister chromatid separation at metaphase II in females. J Cell Biol. 2007 Feb 26;176(5):581-92
• All: 4 reference(s)