Rad51c^tm1.1Sks
Targeted Allele Detail

Summary

• Symbol: Rad51c^tm1.1Sks
• Name: RAD51 paralog C; targeted mutation 1.1, Shyam K Sharan
• MGI ID: MGI:3707425
• Synonyms: Rad51c^ko
• Gene: Rad51c Location: Chr11:87267471-87295780 bp, - strand Genetic Position: Chr11, 52.08 cM
• Alliance: Rad51c^tm1.1Sks page

Testes abnormalities in Rad51c^tm1Sks/Rad51c^tm1.1Sks mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:119835
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exons 2 and 3 are removed by Cre-mediated recombination. The absence of protein product was confirmed by western blot analysis. (J:119835)

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Rad51c^tm1.1Sks

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rad51c Mutation: 24 strains or lines available

References

• Original: J:119835 Kuznetsov S, et al., RAD51C deficiency in mice results in early prophase I arrest in males and sister chromatid separation at metaphase II in females. J Cell Biol. 2007 Feb 26;176(5):581-92
• All: 2 reference(s)