Mesp2^tm9Ysa
Targeted Allele Detail

Summary

• Symbol: Mesp2^tm9Ysa
• Name: mesoderm posterior 2; targeted mutation 9, Yumiko Saga
• MGI ID: MGI:3707532
• Synonyms: F-Mesp2-full
• Gene: Mesp2 Location: Chr7:79460475-79463179 bp, + strand Genetic Position: Chr7, 45.18 cM
• Alliance: Mesp2^tm9Ysa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:119678
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Hypomorph)
• Mutation: Insertion
• Mutation details: The full length protein was expressed, as well as a FLAG tag. A floxed neo included in the vector was subsequently removed via cre mediated recombination. Expression of the knock-in transcript was similar to wild-type in localization, however, expression levels were lower. Likewise, protein expression was lower as well, demonstrating that the allele is a hypomorph. (J:119678)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mesp2 Mutation: 30 strains or lines available

References

• Original: J:119678 Morimoto M, et al., Cooperative Mesp activity is required for normal somitogenesis along the anterior-posterior axis. Dev Biol. 2006 Dec 15;300(2):687-98
• All: 1 reference(s)