Mesp2^tm10Ysa
Targeted Allele Detail

Summary

• Symbol: Mesp2^tm10Ysa
• Name: mesoderm posterior 2; targeted mutation 10, Yumiko Saga
• MGI ID: MGI:3707537
• Synonyms: P2-HD
• Gene: Mesp2 Location: Chr7:79460475-79463179 bp, + strand Genetic Position: Chr7, 45.18 cM
• Alliance: Mesp2^tm10Ysa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:119678
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted
• Mutation: Insertion
• Mutation details: The targeting vector contained the 3xFLAG tag combined with amino acids 61-160 and 311-338, encoding the bHLH and NLS, and degradation domains, respectively. A floxed neo included in the vector was subsequently removed via cre mediated recombination. (J:119678)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mesp2 Mutation: 30 strains or lines available

References

• Original: J:119678 Morimoto M, et al., Cooperative Mesp activity is required for normal somitogenesis along the anterior-posterior axis. Dev Biol. 2006 Dec 15;300(2):687-98
• All: 3 reference(s)