Ikbke^tm1Tman
Targeted Allele Detail

Summary

• Symbol: Ikbke^tm1Tman
• Name: inhibitor of kappaB kinase epsilon; targeted mutation 1, Tom Maniatis
• MGI ID: MGI:3707541
• Synonyms: Ikbke^-
• Gene: Ikbke Location: Chr1:131182337-131207339 bp, - strand Genetic Position: Chr1, 56.93 cM
• Alliance: Ikbke^tm1Tman page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:119791
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129 and C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 4-6 of the targeted gene were replaced with a PGK-neo cassette. Mice show a complete loss of the endogenous kinase function in lung, spleen, and embryonic fibroblasts. (J:119791)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ikbke Mutation: 55 strains or lines available

References

• Original: J:119791 Tenoever BR, et al., Multiple functions of the IKK-related kinase IKKepsilon in interferon-mediated antiviral immunity. Science. 2007 Mar 2;315(5816):1274-8
• All: 21 reference(s)