Ptpn12^tm1Mtr
Targeted Allele Detail

Summary

• Symbol: Ptpn12^tm1Mtr
• Name: protein tyrosine phosphatase, non-receptor type 12; targeted mutation 1, Michel L Tremblay
• MGI ID: MGI:3707593
• Synonyms: PTP-PEST^-
• Gene: Ptpn12 Location: Chr5:21191643-21260909 bp, - strand Genetic Position: Chr5, 9.83 cM, cytoband A3-B
• Alliance: Ptpn12^tm1Mtr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:119668
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 6-9 are replaced with a neo cassette creating a null allele. The absence of protein was confirmed by western blot analysis of homozygous embryos. (J:119668)

Expression

In Mice Carrying this Mutation:	14 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptpn12 Mutation: 52 strains or lines available

References

• Original: J:119668 Sirois J, et al., Essential function of PTP-PEST during mouse embryonic vascularization, mesenchyme formation, neurogenesis and early liver development. Mech Dev. 2006 Dec;123(12):869-80
• All: 2 reference(s)