Smad7^tm1Rheu
Targeted Allele Detail

Summary

• Symbol: Smad7^tm1Rheu
• Name: SMAD family member 7; targeted mutation 1, Rainer L Heuchel
• MGI ID: MGI:3707713
• Synonyms: S7^DEx1, Smad7^-, Smad7^deltaex1
• Gene: Smad7 Location: Chr18:75500600-75529006 bp, + strand Genetic Position: Chr18, 51.06 cM, cytoband E2
• Alliance: Smad7^tm1Rheu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:120714
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Exon 1, containing the ATG, was replaced by a neomycin resistance cassette. (J:120714)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Smad7 Mutation: 53 strains or lines available

References

• Original: J:120714 Li R, et al., Deletion of exon I of SMAD7 in mice results in altered B cell responses. J Immunol. 2006 Jun 1;176(11):6777-84
• All: 13 reference(s)