Sphk1^tm1.1Cgh
Targeted Allele Detail

Summary

• Symbol: Sphk1^tm1.1Cgh
• Name: sphingosine kinase 1; targeted mutation 1, Shaun R Coughlin
• MGI ID: MGI:3707992
• Synonyms: SphK1^-
• Gene: Sphk1 Location: Chr11:116421751-116427501 bp, + strand Genetic Position: Chr11, 81.42 cM, cytoband E2
• Alliance: Sphk1^tm1.1Cgh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:120783
• Parent Cell Line: RF8 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A floxed neo cassette was inserted after exon 2 and a single loxP site was inserted after exon 6. In vivo Cre-mediated recombination then removed the neo cassette and exons 3 through 6 creating a null allele. (J:120783)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sphk1 Mutation: 29 strains or lines available

References

• Original: J:120783 Pappu R, et al., Promotion of lymphocyte egress into blood and lymph by distinct sources of sphingosine-1-phosphate. Science. 2007 Apr 13;316(5822):295-8
• All: 11 reference(s)