Tcrb^tm3Che
Targeted Allele Detail

Summary

• Symbol: Tcrb^tm3Che
• Name: T cell receptor beta chain; targeted mutation 3, Jianzhu Chen
• MGI ID: MGI:3708170
• Synonyms: Vbeta(neo)
• Gene: Tcrb Location: Chr6:40868230-41535305 bp, + strand Genetic Position: Chr6, cytoband A-C

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:120387
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted
• Mutation: Insertion
• Mutation details: The Vbeta13 gene segment with its endogenous promoter and recombination signal sequences and a floxed pgk-neomycin resistance cassette is inserted upstream of the D segment. Insertion was confirmed by Southern blot analysis of ES cells and by increased expression of Vbeta13 T cells in homozygous mice. (J:120387)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Tcrb^tm3Che/Tcrb^tm3Che	involves: 129S4/SvJae

Phenotypes:

Affected Systems	hm1
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immune system	N
immune system phenotype	N

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tcrb Mutation: 97 strains or lines available

References

• Original: J:120387 Sieh P, et al., Distinct control of the frequency and allelic exclusion of the V beta gene rearrangement at the TCR beta locus. J Immunol. 2001 Aug 15;167(4):2121-9
• All: 1 reference(s)