Adamts13^tm2Dgi
Targeted Allele Detail

Summary

• Symbol: Adamts13^tm2Dgi
• Name: ADAM metallopeptidase with thrombospondin type 1 motif 13; targeted mutation 2, David Ginsburg
• MGI ID: MGI:3708852
• Synonyms: Adamts13^conditional, Adamts13/delta Neo
• Gene: Adamts13 Location: Chr2:26863428-26899640 bp, + strand Genetic Position: Chr2, 19.14 cM
• Alliance: Adamts13^tm2Dgi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:101752
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 3 of Adamts13 was flanked with LoxP sequences (plus an additonal LoxP located 511 bp 3'). In addition, a floxed neomycin cassette was inserted between exons 2 and 3. (J:101752)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Adamts13 Mutation: 70 strains or lines available

References

• Original: J:101752 Motto DG, et al., Shigatoxin triggers thrombotic thrombocytopenic purpura in genetically susceptible ADAMTS13-deficient mice. J Clin Invest. 2005 Oct;115(10):2752-61
• All: 1 reference(s)