Ggcx^tm1Dgi
Targeted Allele Detail

Summary

• Symbol: Ggcx^tm1Dgi
• Name: gamma-glutamyl carboxylase; targeted mutation 1, David Ginsburg
• MGI ID: MGI:3708899
• Synonyms: Ggcx^-
• Gene: Ggcx Location: Chr6:72391291-72407695 bp, + strand Genetic Position: Chr6, 32.27 cM, cytoband C3
• Alliance: Ggcx^tm1Dgi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:120784
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• A neomycin resistance gene was used to replace exons 3-13 of the gene. (J:120784)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ggcx Mutation: 37 strains or lines available

References

• Original: J:120784 Zhu A, et al., Fatal hemorrhage in mice lacking gamma-glutamyl carboxylase. Blood. 2007 Jun 15;109(12):5270-5
• All: 1 reference(s)