repro46
Chemically induced Allele Detail

Summary

• Symbol: repro46
• Name: reproductive mutant 46, JAX Reproductive Mutagenesis Program
• MGI ID: MGI:3708995
• Gene: repro46 Location: Chr9:50665038-56808939 bp Genetic Position: Chr9, Syntenic
• Alliance: repro46 page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Undefined
• This phenotypic mutant was identified in an ENU mutagenesis screen.
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any repro46 Mutation: 0 strains or lines available

Notes

Males and females are infertile: very low testis weight, low seminal vesicle weight, no epididymal sperm are recovered; in females, no oocytes are recovered. Histological analysis shows arrest of spermatogenesis during late pachytene stage of meiotic prophase, some seminiferous tubules have only spermatogonia and Sertoli cells present, some germ cells appear apoptotic. Ovaries are tiny with some follicle activity; hemorrhagic cysts are present in some ovaries.

References

• Original: J:92463 JAX Reproductive Mutagenesis Program, Heritable mouse mutants from The Jackson Laboratory Reproductive Genomics Mutagenesis Program. MGI Direct Data Submission. 2004-7
• All: 1 reference(s)