Tg(tetO-APPSwInd)18Dbo
Transgene Detail
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Symbol: |
Tg(tetO-APPSwInd)18Dbo |
Name: |
transgene insertion 18, David R Borchelt |
MGI ID: |
MGI:3709065 |
Synonyms: |
tet-APPswe/ind line 18, Tg(tetO-APP*Swe*Ind)18Dbo |
Transgene: |
Tg(tetO-APPSwInd)18Dbo Location: unknown
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Alliance: |
Tg(tetO-APPSwInd)18Dbo page
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Transgene Type: |
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Transgenic (Humanized sequence, Inducible, Inserted expressed sequence) |
Inducer: |
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doxycycline/tetracycline |
Mutation: |
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Insertion
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Tg(tetO-APPSwInd)18Dbo expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Note |
mouse |
App (MGI:88059) |
The gene encodes a humanized amyloid beta domain and incorporates the Swedish mutation. |
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Tg(tetO-APPSwInd)18Dbo expression driven by
1 gene
Transgene expression driven by:
Organism |
Driver Gene |
Note |
Not Specified |
tetO |
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Mutation details: The mouse amyloid beta (A4) precursor protein (APP) sequence was modified to contain a humanized amyloid-beta (Abeta) domain. This mouse/human chimeric APP (mo/huAPP695 or APP695) was mutated to incorporate the Swedish (KM570/571NL) and Indiana (V617F) APP mutations associated with Alzheimer's disease. This APP695swe/ind sequence was placed downstream of the tetracycline-responsive (TRE or tetO) promoter and mouse prion protein exons 1-2.
(J:109829)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Original: |
J:109829 Jankowsky JL, et al., Persistent amyloidosis following suppression of Abeta production in a transgenic model of Alzheimer disease. PLoS Med. 2005 Dec;2(12):e355 |
All: |
1 reference(s) |
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