Tg(Camk2a-Bdnf)A9Stl
Transgene Detail

Summary

• Symbol: Tg(Camk2a-Bdnf)A9Stl
• Name: transgene insertion A9, Susumu Tonegawa
• MGI ID: MGI:3709467
• Transgene: Tg(Camk2a-Bdnf)A9Stl Location: unknown
• Alliance: Tg(Camk2a-Bdnf)A9Stl page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Camk2a-Bdnf)A9Stl expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  rat

  Bdnf (24225)

  Bdnf	(MGI:88145)

• Mutation details: The transgene construct has the rat Bdnf cDNA sequence, with a Kozak sequence inserted in front of the translation initiation site, controlled by the mouse Camk2a promoter. The SV40 intron/polyA sequence was inserted the 3' to the Bdnf cDNA. ISH demonstrated that Bdnf overexpression is mainly restricted to the forebrain regions, including all of the neocortex, parts of the hippocampus, amygdala and striatum. (J:57645)

Disease models

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:57645 Huang ZJ, et al., BDNF regulates the maturation of inhibition and the critical period of plasticity in mouse visual cortex. Cell. 1999 Sep 17;98(6):739-55
• All: 10 reference(s)