Mybl1^tm1.1Wtsn
Targeted Allele Detail

Summary

• Symbol: Mybl1^tm1.1Wtsn
• Name: myeloblastosis oncogene-like 1; targeted mutation 1.1, R J Watson
• MGI ID: MGI:3709838
• Synonyms: B-myb^mE2F
• Gene: Mybl1 Location: Chr1:9737640-9770434 bp, - strand Genetic Position: Chr1, 2.08 cM
• Alliance: Mybl1^tm1.1Wtsn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:121059
• Parent Cell Line: TL1/TL-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutation: Nucleotide substitutions
• Mutation details: An FRT-flanked neo was removed via Flp mediated recombination, leaving point mutations in the E2F site and the non-coding sequence of exon 1. Expression of transcript was as high, if not higher, than wild-type. (J:121059)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mybl1 Mutation: 34 strains or lines available

References

• Original: J:121059 Tavner F, et al., Targeting an E2F site in the mouse genome prevents promoter silencing in quiescent and post-mitotic cells. Oncogene. 2007 Apr 26;26(19):2727-35
• All: 1 reference(s)