Gt(ROSA)26Sor^{tm1(Mirn155)Rsky}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(Mirn155)Rsky}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Klaus Rajewsky
• MGI ID: MGI:3709879
• Synonyms: B-cell^mir155, Gt(ROSA)26Sor^{tm1(Mir155)Rsky}
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(Mirn155)Rsky} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:121084
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1(Mirn155)Rsky} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Mir155 (MGI:2676840)

• Mutation details: A vector containing the CAG promoter, a floxed neo and transcriptional STOP cassette, and microRNA 155 cDNA was inserted into the locus. An frt-flanked IRES-EGFP and polyA signal were placed downstream of the microRNA 155 cDNA. (J:121084)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 993 strains or lines available

References

• Original: J:121084 Thai TH, et al., Regulation of the germinal center response by microRNA-155. Science. 2007 Apr 27;316(5824):604-8
• All: 6 reference(s)