Dnm1^tm1Pdc
Targeted Allele Detail

Summary

• Symbol: Dnm1^tm1Pdc
• Name: dynamin 1; targeted mutation 1, Pietro De Camilli
• MGI ID: MGI:3709883
• Gene: Dnm1 Location: Chr2:32198483-32243350 bp, - strand Genetic Position: Chr2, 22.09 cM
• Alliance: Dnm1^tm1Pdc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:121111
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to replace exon 1 with a neomycin resistance cassette. Immunoblot confirmed absence of protein in mutant brains. (J:121111)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dnm1 Mutation: 40 strains or lines available

References

• Original: J:121111 Ferguson SM, et al., A selective activity-dependent requirement for dynamin 1 in synaptic vesicle endocytosis. Science. 2007 Apr 27;316(5824):570-4
• All: 11 reference(s)