Cbl^tm1Dejs
Targeted Allele Detail

Summary

• Symbol: Cbl^tm1Dejs
• Name: Casitas B-lineage lymphoma; targeted mutation 1, David E James
• MGI ID: MGI:3709884
• Synonyms: c-Cbl^F, c-Cbl(Y737F), cCbl^YF
• Gene: Cbl Location: Chr9:44054273-44145346 bp, - strand Genetic Position: Chr9, 24.72 cM
• Alliance: Cbl^tm1Dejs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:121012
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutation: Nucleotide substitutions
• Mutation details: A Y737F substitution was introduced into the locus. The Y737F substitution (Y731F in the human CBL protein) ablates the binding site of the p85 subunit of PI 3-kinase to Cbl, as well as the Cbl-mediated activation of this lipid kinase in several cell types. (J:121012)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cbl Mutation: 59 strains or lines available

References

• Original: J:121012 Molero JC, et al., Genetic ablation of the c-Cbl ubiquitin ligase domain results in increased energy expenditure and improved insulin action. Diabetes. 2006 Dec;55(12):3411-7
• All: 11 reference(s)