Atp2b4^tm1Ksch
Targeted Allele Detail

Summary

• Symbol: Atp2b4^tm1Ksch
• Name: ATPase, Ca++ transporting, plasma membrane 4; targeted mutation 1, Kai Schuh
• MGI ID: MGI:3709898
• Synonyms: Pmca4^-
• Gene: Atp2b4 Location: Chr1:133630416-133728755 bp, - strand Genetic Position: Chr1, 57.95 cM
• Alliance: Atp2b4^tm1Ksch page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:121031
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to replace exon 2 and part of exon 3 with a neomycin resistance gene. Western blot confirmed absence of protein in mutant testis. (J:121031)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Atp2b4 Mutation: 55 strains or lines available

References

• Original: J:121031 Schuh K, et al., Plasma membrane Ca2+ ATPase 4 is required for sperm motility and male fertility. J Biol Chem. 2004 Jul 2;279(27):28220-6
• All: 6 reference(s)