Gucy2f^tm1Wbae
Targeted Allele Detail

Summary

• Symbol: Gucy2f^tm1Wbae
• Name: guanylate cyclase 2f; targeted mutation 1, Wolfgang Baehr
• MGI ID: MGI:3709985
• Synonyms: GC2^-, RetGC2^-
• Gene: Gucy2f Location: ChrX:140864156-140979927 bp, - strand Genetic Position: ChrX, 62.85 cM
• Alliance: Gucy2f^tm1Wbae page

Abnormal rod outer segments in Gucy2e^tm1Gar/Gucy2e^tm1Gar Gucy2f^tm1Wbae/Gucy2f^tm1Wbae mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:120903
• Parent Cell Line: iTL1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced the ATG and peptide leader sequence encoded by exon 2. Immunoblot confirmed absence of protein in mutant retinal lysates. (J:120903)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gucy2f Mutation: 4 strains or lines available

References

• Original: J:120903 Baehr W, et al., The function of guanylate cyclase 1 and guanylate cyclase 2 in rod and cone photoreceptors. J Biol Chem. 2007 Mar 23;282(12):8837-47
• All: 7 reference(s)