Lgr4^{Gt(pU-21)1Kymm}
Gene trapped Allele Detail

Summary

• Symbol: Lgr4^{Gt(pU-21)1Kymm}
• Name: leucine-rich repeat-containing G protein-coupled receptor 4; gene trap 1, Ken-ichi Yamamura
• MGI ID: MGI:3709988
• Synonyms: Lgr4^Gt, Lgr4^{GtAyu21-127Imeg}
• Gene: Lgr4 Location: Chr2:109747992-109844602 bp, + strand Genetic Position: Chr2, 56.65 cM
• Alliance: Lgr4^{Gt(pU-21)1Kymm} page

Mutation origin

• Mutant Cell Line: Ayu21-127
• Germline Transmission: Earliest citation of germline transmission: J:121125
• Parent Cell Line: KTPU10 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Gene trapped (Hypomorph, Reporter)
• Mutation: Insertion of gene trap vector
• Mutation details: A gene trap vector containing a splice acceptor, betageo, polyA, loxP site, FRT-flanked polyA, lox2272 site, pSP73 and a lox511 site was inserted into intron 2 of the locus. The integration event resulted in either a 628- or 562-bp deletion in the 5' or 3' region of the vector, respectively. No deletion occurred in the genomic region around the insertion site. This allele is a hypomorph. (J:121125)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  Ayu21-127	AB520833 ; (MGI Seq Detail)	5' RACE	Chr2:109748560-109815010 bp (+)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  67 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lgr4 Mutation: 94 strains or lines available

References

• Original: J:121125 Hoshii T, et al., LGR4 Regulates the Postnatal Development and Integrity of Male Reproductive Tracts in Mice. Biol Reprod. 2007 Feb;76(2):303-13
• All: 4 reference(s)