Abca3^tm1Nina
Targeted Allele Detail

Summary

• Symbol: Abca3^tm1Nina
• Name: ATP-binding cassette, sub-family A member 3; targeted mutation 1, Nobuya Inagaki
• MGI ID: MGI:3709991
• Synonyms: Abca3^-
• Gene: Abca3 Location: Chr17:24570997-24629178 bp, + strand Genetic Position: Chr17, 12.38 cM, cytoband A3.3
• Alliance: Abca3^tm1Nina page

Lung abnormalities in Abca3^tm1Nina/Abca3^tm1Nina mice, including pulmonary congestion and atelectasis

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:121155
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A pgk-neo cassette was inserted to replace a 2948-bp fragment containing the four exons encoding the first nucleotide-binding domain. Absence of protein was confirmed by immunoblot of mutant lung tissue. (J:121155)

Disease models

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Abca3 Mutation: 92 strains or lines available

References

• Original: J:121155 Ban N, et al., ABCA3 as a lipid transporter in pulmonary surfactant biogenesis. J Biol Chem. 2007 Mar 30;282(13):9628-34
• All: 1 reference(s)