Rasa3^tm1Shiw
Targeted Allele Detail

Summary

• Symbol: Rasa3^tm1Shiw
• Name: RAS p21 protein activator 3; targeted mutation 1, Shintaro Iwashita
• MGI ID: MGI:3710014
• Synonyms: R-Ras gap^-
• Gene: Rasa3 Location: Chr8:13617218-13727590 bp, - strand Genetic Position: Chr8, 6.29 cM
• Alliance: Rasa3^tm1Shiw page

Rasa3^tm1Shiw/Rasa3^tm1Shiw mice exhibit edema and hemorrhaging in the head and trunk

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:120930
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 11-12 were replaced with a neomycin resistance cassette. As expected, Northern blot and immunoblot analyses detected a transcript lacking 264 nucleotides corresponding to 88 amino acids without frameshift. (J:120930)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rasa3 Mutation: 62 strains or lines available

References

• Original: J:120930 Iwashita S, et al., Versatile roles of R-Ras GAP in neurite formation of PC12 cells and embryonic vascular development. J Biol Chem. 2007 Feb 9;282(6):3413-7
• All: 2 reference(s)