Ncaph2^nes
Chemically induced Allele Detail

Summary

• Symbol: Ncaph2^nes
• Name: non-SMC condensin II complex, subunit H2; nessy
• MGI ID: MGI:3710093
• Synonyms: kleisin beta^nes, Ncaph2^I15N, nes
• Gene: Ncaph2 Location: Chr15:89239922-89257029 bp, + strand Genetic Position: Chr15, 44.84 cM
• Alliance: Ncaph2^nes page

Mutation origin

• Strain of Origin: C57BL/6JSfdAnu
• Project Collection: APF ENU Mutagenesis

Mutation description

• Allele Type: Chemically induced (ENU) (Hypomorph)
• Mutation: Single point mutation
• Mutation details: T to A substitution in exon 1 at 44th base following the first ATG (note that there are two ATG transcriptional start sites for this gene, resulting in three alternate amino acid sequences for exon 1) (J:123300)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Ncaph2 Mutation: 38 strains or lines available

References

• Original: J:123300 Gosling KM, et al., A mutation in a chromosome condensin II subunit, kleisin beta, specifically disrupts T cell development. Proc Natl Acad Sci U S A. 2007 Jul 24;104(30):12445-50
• All: 5 reference(s)