Cxcr6^tm1Lex
Targeted Allele Detail

Summary

• Symbol: Cxcr6^tm1Lex
• Name: C-X-C motif chemokine receptor 6; targeted mutation 1, Lexicon Genetics
• MGI ID: MGI:3710094
• Synonyms: Cxcr6^-
• Gene: Cxcr6 Location: Chr9:123635542-123640819 bp, + strand Genetic Position: Chr9, 74.57 cM, cytoband F
• Alliance: Cxcr6^tm1Lex page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:120952
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to replace exon 2 with a lacZ/neo. RT-PCR confirmed absence of wild-type transcript in mutants. (J:120952)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cxcr6 Mutation: 33 strains or lines available

References

• Original: J:120952 Sasai K, et al., Medulloblastomas derived from Cxcr6 mutant mice respond to treatment with a smoothened inhibitor. Cancer Res. 2007 Apr 15;67(8):3871-7
• All: 1 reference(s)