Gt(ROSA)26Sor^{tm3(SS18/EGFP)Mrc}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm3(SS18/EGFP)Mrc}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 3, Mario R Capecchi
• MGI ID: MGI:3710098
• Synonyms: Rosa26^hSS2, SSM2
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm3(SS18/EGFP)Mrc} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:120967
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, Humanized sequence, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm3(SS18/EGFP)Mrc} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  SS18 (6760)

  Ss18	(MGI:107708)

• Mutation details: These mice express human synovial sarcoma translocation, chromosome 18-IRES-EGFP bicistronic mRNA from the ROSA promoter. The vector also contained a strong transcriptional termination signal, NeoPA, flanked by loxP sites, such that the inserted cDNA is not transcribed without the presence of cre recombinase. (J:120967)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Gt(ROSA)26Sor^{tm3(SS18/EGFP)Mrc}

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 993 strains or lines available

References

• Original: J:120967 Haldar M, et al., A conditional mouse model of synovial sarcoma: insights into a myogenic origin. Cancer Cell. 2007 Apr;11(4):375-88
• All: 5 reference(s)