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Ptprrtm1Wjh
Targeted Allele Detail
Summary
Symbol: Ptprrtm1Wjh
Name: protein tyrosine phosphatase receptor type R; targeted mutation 1, Wiljan J A J Hendriks
MGI ID: MGI:3710117
Synonyms: Ptprr-
Gene: Ptprr  Location: Chr10:115854118-116110837 bp, + strand  Genetic Position: Chr10, 64.01 cM, cytoband A2
Alliance: Ptprrtm1Wjh page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:121302
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 6 was replaced by a neomycin resistance cassette. With the gene having 3 transcription start sites, loss of exon 6 would shift the reading frame in any residual transcript. Northern blot, immunoprecipitation and immunoblot confirmed absence of all isoforms in mutants. (J:121302)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ptprr Mutation:  38 strains or lines available
References
Original:  J:121302 Chirivi RG, et al., Altered MAP kinase phosphorylation and impaired motor coordination in PTPRR deficient mice. J Neurochem. 2007 May;101(3):829-40
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory