Tg(Wap-Tsg101)4389Kuw
Transgene Detail

Summary

• Symbol: Tg(Wap-Tsg101)4389Kuw
• Name: transgene insertion 4389, Kay-Uwe Wagner
• MGI ID: MGI:3710126
• Transgene: Tg(Wap-Tsg101)4389Kuw Location: unknown
• Alliance: Tg(Wap-Tsg101)4389Kuw page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Wap-Tsg101)4389Kuw expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Tsg101 (MGI:106581)

• Mutation details: An HA-tagged Tsg101 cDNA was cloned into the blunted Asp718 and SalI sites of a WAP-based mammary specific expression vector replacing exons 1-3 of WAP. Expression of Tsg101 is thus under the control of the WAP promoter. (J:121475)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(Wap-Tsg101)4389Kuw

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:121475 Oh KB, et al., Tsg101 is upregulated in a subset of invasive human breast cancers and its targeted overexpression in transgenic mice reveals weak oncogenic properties for mammary cancer initiation. Oncogene. 2007 Aug 30;26(40):5950-9
• All: 1 reference(s)