Gucy1b1^tm1.1Frb
Targeted Allele Detail

Summary

• Symbol: Gucy1b1^tm1.1Frb
• Name: guanylate cyclase 1, soluble, beta 1; targeted mutation 1.1, Andreas Friebe
• MGI ID: MGI:3710142
• Synonyms: GCKO
• Gene: Gucy1b1 Location: Chr3:81939313-81981996 bp, - strand Genetic Position: Chr3, 35.97 cM
• Alliance: Gucy1b1^tm1.1Frb page

Decreased body weight and survival of Gucy1b1^tm1.1Frb/Gucy1b1^tm1.1Frb mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:121321
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exon 10 was flanked by loxP sites and subsequently removed via cre excision in the germline. Neither the beta1 subunit or the alpha subunits could be detected at the protein level. (J:121321)

Expression

In Structures Affected by this Mutation:

10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gucy1b1 Mutation: 42 strains or lines available

References

• Original: J:121321 Friebe A, et al., Fatal gastrointestinal obstruction and hypertension in mice lacking nitric oxide-sensitive guanylyl cyclase. Proc Natl Acad Sci U S A. 2007 May 1;104(18):7699-704
• All: 11 reference(s)