Del(12Bdkrb2-Bdkrb1)1Mki
Targeted Allele Detail

Summary

• Symbol: Del(12Bdkrb2-Bdkrb1)1Mki
• Name: deletion, Chr 12, Masao Kakoki 1
• MGI ID: MGI:3710158
• Synonyms: B1RB2R-null, Bdkrb1^-/Bdkrb2^-, Bdkrb2/Bdkrb1^tm1Mki
• Gene: Del(12Bdkrb2-Bdkrb1)1Mki Location: unknown Genetic Position: Chr12, Syntenic

Histological changes in the postischemic kidneys of wild type, Bdkrb2^tm1Jfh/Bdkrb2^tm1Jfh and MGI:3710159/MGI:3710159 mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:121339
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intergenic deletion, Intragenic deletion
• Del(12Bdkrb2-Bdkrb1)1Mki involves 2 genes/genome features (Bdkrb2, Bdkrb1) View all
• Mutation details: A targeting vector was designed to replace bradykinin receptor, beta 2 exon 3 and the bradykinin receptor, beta 1 exon with a floxed neomycin resistance cassette. (J:121339)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Del(12Bdkrb2-Bdkrb1)1Mki Mutation: 1 strain or line available

References

• Original: J:121339 Kakoki M, et al., Bradykinin B1 and B2 receptors both have protective roles in renal ischemia/reperfusion injury. Proc Natl Acad Sci U S A. 2007 May 1;104(18):7576-81
• All: 5 reference(s)