Slc4a4^tm1Ges
Targeted Allele Detail

Summary

• Symbol: Slc4a4^tm1Ges
• Name: solute carrier family 4 (anion exchanger), member 4; targeted mutation 1, Gary E Shull
• MGI ID: MGI:3710188
• Synonyms: Nbc1^-, NBCe1^-
• Gene: Slc4a4 Location: Chr5:89034345-89387512 bp, + strand Genetic Position: Chr5, 44.1 cM, cytoband E2
• Alliance: Slc4a4^tm1Ges page

Follicular organization of the spleen is disrupted in Slc4a4^tm1Ges/Slc4a4^tm1Ges mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:120867
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Part of exon 9 was replaced with a neomycin resistance gene. Absence of transcript was confirmed by Northern blot of mutant kidney, small intestine and colon. (J:120867)

Expression

In Structures Affected by this Mutation:

10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Slc4a4 Mutation: 80 strains or lines available

References

• Original: J:120867 Gawenis LR, et al., Colonic anion secretory defects and metabolic acidosis in mice lacking the NBC1 Na+/HCO3- cotransporter. J Biol Chem. 2007 Mar 23;282(12):9042-52
• All: 17 reference(s)