Rho^tm1Shda
Targeted Allele Detail

Summary

• Symbol: Rho^tm1Shda
• Name: rhodopsin; targeted mutation 1, Yoshinori Shichida
• MGI ID: MGI:3710193
• Synonyms: E112Q
• Gene: Rho Location: Chr6:115908709-115916997 bp, + strand Genetic Position: Chr6, 53.72 cM
• Alliance: Rho^tm1Shda page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:120882
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Hypomorph, Modified isoform(s))
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: A targeting vector was designed to replace glutamate 122 with glutamine (E122Q) in exon 2, and to add a neomycin resistance gene into intron 1 in reverse direction. (J:120882)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rho Mutation: 51 strains or lines available

References

• Original: J:120882 Imai H, et al., Molecular properties of rhodopsin and rod function. J Biol Chem. 2007 Mar 2;282(9):6677-84
• All: 2 reference(s)