Adamts5^tm1.1Lex
Targeted Allele Detail

Summary

• Symbol: Adamts5^tm1.1Lex
• Name: ADAM metallopeptidase with thrombospondin type 1 motif 5; targeted mutation 1.1, Lexicon Genetics
• MGI ID: MGI:3710194
• Synonyms: ADAMTS-5-delta-cat, ADAMTS-5-deltacat, ADAMTS5 delta-cat
• Gene: Adamts5 Location: Chr16:85655045-85698013 bp, - strand Genetic Position: Chr16, 48.34 cM
• Alliance: Adamts5^tm1.1Lex page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:120892
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Exon 3 was removed via cre mediated recombination. (J:120892)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adamts5 Mutation: 56 strains or lines available

References

• Original: J:120892 East CJ, et al., ADAMTS-5 deficiency does not block aggrecanolysis at preferred cleavage sites in the chondroitin sulfate-rich region of aggrecan. J Biol Chem. 2007 Mar 23;282(12):8632-40
• All: 4 reference(s)