Sptbn4^tm1Mkom
Targeted Allele Detail

Summary

• Symbol: Sptbn4^tm1Mkom
• Name: spectrin beta, non-erythrocytic 4; targeted mutation 1, Masayuki Komada
• MGI ID: MGI:3710201
• Synonyms: sigma 1^-
• Gene: Sptbn4 Location: Chr7:27055808-27147111 bp, - strand Genetic Position: Chr7, 15.88 cM, cytoband A3
• Alliance: Sptbn4^tm1Mkom page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:120916
• Parent Cell Line: AK7 (ES Cell)
• Strain of Origin: 129S4/SvJaeSor

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The sigma 1-specific targeting vector was designed to replace exon 1 and part of exon 2 with a neomycin resistance cassette in reverse orientation. Immunoblot confirmed the absence of the sigma 1 isoform, and the normal expression of the sigma 6 isoform. (J:120916)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sptbn4 Mutation: 122 strains or lines available

References

• Original: J:120916 Uemoto Y, et al., Specific role of the truncated betaIV-spectrin Sigma6 in sodium channel clustering at axon initial segments and nodes of ranvier. J Biol Chem. 2007 Mar 2;282(9):6548-55
• All: 1 reference(s)