Dlg1^tm1Taki
Targeted Allele Detail

Summary

• Symbol: Dlg1^tm1Taki
• Name: discs large MAGUK scaffold protein 1; targeted mutation 1, Tetsu Akiyama
• MGI ID: MGI:3710242
• Synonyms: Dlgh1^-
• Gene: Dlg1 Location: Chr16:31482261-31692174 bp, + strand Genetic Position: Chr16, 22.4 cM
• Alliance: Dlg1^tm1Taki page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:121262
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin resistance cassette was inserted into exon 3 in frame. RT-PCR confirmed insertion of the neo and absence of protein was demonstrated by Western blot analysis. (J:121262)

Expression

In Mice Carrying this Mutation:	41 assay results
In Structures Affected by this Mutation:	13 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dlg1 Mutation: 76 strains or lines available

References

• Original: J:121262 Iizuka-Kogo A, et al., Abnormal development of urogenital organs in Dlgh1-deficient mice. Development. 2007 May;134(9):1799-807
• All: 3 reference(s)