Tbx3^{tm1.1(cre)Vmc}
Targeted Allele Detail

Summary

• Symbol: Tbx3^{tm1.1(cre)Vmc}
• Name: T-box 3; targeted mutation 1.1, Vincent M Christoffels
• MGI ID: MGI:3710254
• Synonyms: Tbx3^cre
• Gene: Tbx3 Location: Chr5:119808734-119822789 bp, + strand Genetic Position: Chr5, 60.34 cM
• Alliance: Tbx3^{tm1.1(cre)Vmc} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:121230
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Tbx3^{tm1.1(cre)Vmc} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Tbx3 (MGI:98495)

• Mutation details: A cre recombinase cDNA was inserted upstream to replace the first 3 codons in exon 1. A floxed neo was removed by Flp recombinase in the germline. (J:121230)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Tbx3 (mouse) Summary of all recombinase alleles driven by Tbx3. Alliance mouse Tbx3 gene page

Expression

In Mice Carrying this Mutation:	3 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tbx3 Mutation: 49 strains or lines available

References

• Original: J:121230 Hoogaars WM, et al., Tbx3 controls the sinoatrial node gene program and imposes pacemaker function on the atria. Genes Dev. 2007 May 1;21(9):1098-112
• All: 8 reference(s)