Tg(Nppa-cre)4Vmc
Transgene Detail

Summary

• Symbol: Tg(Nppa-cre)4Vmc
• Name: transgene insertion 4, Vincent M Christoffels
• MGI ID: MGI:3710255
• Synonyms: Nppa-cre4
• Transgene: Tg(Nppa-cre)4Vmc Location: unknown
• Alliance: Tg(Nppa-cre)4Vmc page

Transgene origin

• Strain of Origin: Not Applicable

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Nppa-cre)4Vmc expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Nppa (MGI:97367)

• Mutation details: The transgenic construct consisted of a sequence fragment encoding cre recombinase, a nuclear localization signal, and a consensus Kozak signal inserted at the start codon of the mouse genomic Nppa sequence. The 0.7 kbp Nppa proximal promoter region (-3kbp to +4 kbp relative to the transcription start site) was included. The mouse Nppa proximal promoter drives expression of cre recombinase in atrial cardiomyocytes beginning around E10.5. Complete expression is observed around E14.5. Some expression was observed in the inflow tract. (J:86158)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Nppa (mouse) Summary of all recombinase alleles driven by Nppa. Comparative matrix view of recombinase activities Alliance mouse Nppa gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:86158 de Lange FJ, et al., Atrial cardiomyocyte-specific expression of Cre recombinase driven by an Nppa gene fragment. Genesis. 2003 Sep;37(1):1-4
• All: 3 reference(s)