Epas1^tm1.1Mcs
Targeted Allele Detail

Summary

• Symbol: Epas1^tm1.1Mcs
• Name: endothelial PAS domain protein 1; targeted mutation 1.1, M Celeste Simon
• MGI ID: MGI:3710344
• Synonyms: Hif-2a^delta
• Gene: Epas1 Location: Chr17:87061292-87140838 bp, + strand Genetic Position: Chr17, 56.9 cM
• Alliance: Epas1^tm1.1Mcs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:119731
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exon 2 was deleted by a recombination event when 3LoxP founders were crossed to Tg(EIIa-cre)C5379 mice to remove the floxed Neo cassette during creation of the floxed (tm1Mcs) allele. (J:119731)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Epas1^tm1.1Mcs

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Epas1 Mutation: 66 strains or lines available

References

• Original: J:119731 Gruber M, et al., Acute postnatal ablation of Hif-2alpha results in anemia. Proc Natl Acad Sci U S A. 2007 Feb 13;104(7):2301-6
• All: 4 reference(s)