Spen^tm2.1Hon
Targeted Allele Detail

Summary

• Symbol: Spen^tm2.1Hon
• Name: spen family transcription repressor; targeted mutation 2.1, Tasuku Honjo
• MGI ID: MGI:3710413
• Synonyms: MINT cko, Mint^f
• Gene: Spen Location: Chr4:141195201-141265908 bp, - strand Genetic Position: Chr4, 74.26 cM, cytoband E1
• Alliance: Spen^tm2.1Hon page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:121523
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: ES cells containing the Spen^tm2Hon allele were infected with adenovirus expressing cre at low levels. This resulted in removal of the neomycin expression vector and left exon 11 flanked by loxP sites. (J:121523)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Spen Mutation: 140 strains or lines available

References

• Original: J:121523 Yabe D, et al., Generation of a conditional knockout allele for mammalian Spen protein Mint/SHARP. Genesis. 2007 May;45(5):300-6
• All: 4 reference(s)