Tg(Myh6-Ccnd2)1Ljf
Transgene Detail

Summary

• Symbol: Tg(Myh6-Ccnd2)1Ljf
• Name: transgene insertion 1, Loren J Field
• MGI ID: MGI:3710481
• Synonyms: MHC-cycD2
• Transgene: Tg(Myh6-Ccnd2)1Ljf Location: unknown
• Alliance: Tg(Myh6-Ccnd2)1Ljf page

Transgene origin

• Strain of Origin: C3HeB/FeJ

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myh6-Ccnd2)1Ljf expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Ccnd2 (MGI:88314)

• Mutation details: This transgene consists of the mouse alpha-cardiac myosin heavy chain promoter driving the expression of the mouse cyclin D2 gene in the heart. 8 transgenic lines were made. Western blot analysis confirmed expression in the heart. (J:104622)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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tg1	Tg(Myh6-Ccnd2)1Ljf/0	involves: C3HeB/FeJ * DBA/2J

Phenotypes:

Affected Systems	tg1
show or hide all annotated terms
cardiovascular system	√
increased heart weight	√
abnormal myocardial fiber physiology	√
abnormal response to cardiac infarction	√
decreased myocardial infarct size	√
growth/size/body	√
increased heart weight	√
homeostasis/metabolism	√
abnormal response to cardiac infarction	√
decreased myocardial infarct size	√

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:104622 Pasumarthi KB, et al., Targeted expression of cyclin D2 results in cardiomyocyte DNA synthesis and infarct regression in transgenic mice. Circ Res. 2005 Jan 7;96(1):110-8
• All: 6 reference(s)