Bicc1^tm1Emdr
Targeted Allele Detail

Summary

• Symbol: Bicc1^tm1Emdr
• Name: BicC family RNA binding protein 1; targeted mutation 1, E M de Robertis
• MGI ID: MGI:3711021
• Synonyms: BicC
• Gene: Bicc1 Location: Chr10:70758662-70995530 bp, - strand Genetic Position: Chr10, 36.75 cM
• Alliance: Bicc1^tm1Emdr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:121683
• Parent Cell Line: LW1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A targeting vector was used to place an in-frame LacZ reporter gene in the first exon of the gene at the initiator methionine and insert a neomycin resistance cassette downstream of the LacZ cassette downstream of exon 8. LacZ expression was observed in the Henson's node at embryonic day 7.5 and in the endoderm of the gut at embryonic day 8.5 (J:121683)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Bicc1 Mutation: 65 strains or lines available

References

• Original: J:121683 de Robertis EM, A targeted mutation of Bicc1. MGI Direct Data Submission. 2007
• All: 2 reference(s)