Trbv13-2^tm1(CD2)Zhu
Targeted Allele Detail

Summary

• Symbol: Trbv13-2^tm1(CD2)Zhu
• Name: T cell receptor beta, variable 13-2; targeted mutation 1, Yuan Zhuang
• MGI ID: MGI:3711047
• Synonyms: Vbeta8.2^CD2
• Gene: Trbv13-2 Location: Chr6:41098330-41098766 bp, + strand Genetic Position: Chr6, 19.2 cM
• Alliance: Trbv13-2^tm1(CD2)Zhu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:121608
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted
• Mutation: Insertion
• Mutation details: Human CD2 cDNA driven by an IRES was inserted 1.5 kbp upstream of the putative polyA site and 104 bp downstream of the RSS such that the human CD2 would be expressed exclusively from the germline transcription and will be deleted after recombination involving Tcrb-V8.2 or any upstream Tcrb gene. (J:121608)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trbv13-2 Mutation: 10 strains or lines available

Notes

ES cell line = YZ-C22

References

• Original: J:121608 Jia J, et al., Germline transcription from T-cell receptor Vbeta gene is uncoupled from allelic exclusion. EMBO J. 2007 May 2;26(9):2387-99
• All: 2 reference(s)