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Trbv13-2tm1(CD2)Zhu
Targeted Allele Detail
Summary
Symbol: Trbv13-2tm1(CD2)Zhu
Name: T cell receptor beta, variable 13-2; targeted mutation 1, Yuan Zhuang
MGI ID: MGI:3711047
Synonyms: Vbeta8.2CD2
Gene: Trbv13-2  Location: Chr6:41098330-41098766 bp, + strand  Genetic Position: Chr6, 19.2 cM
Alliance: Trbv13-2tm1(CD2)Zhu page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:121608
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted
Mutation:    Insertion
 
Mutation detailsHuman CD2 cDNA driven by an IRES was inserted 1.5 kbp upstream of the putative polyA site and 104 bp downstream of the RSS such that the human CD2 would be expressed exclusively from the germline transcription and will be deleted after recombination involving Tcrb-V8.2 or any upstream Tcrb gene. (J:121608)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Trbv13-2 Mutation:  10 strains or lines available
Notes
ES cell line = YZ-C22
References
Original:  J:121608 Jia J, et al., Germline transcription from T-cell receptor Vbeta gene is uncoupled from allelic exclusion. EMBO J. 2007 May 2;26(9):2387-99
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory