Gli3^tm2Blnw
Targeted Allele Detail

Summary

• Symbol: Gli3^tm2Blnw
• Name: GLI-Kruppel family member GLI3; targeted mutation 2, Baolin Wang
• MGI ID: MGI:3711052
• Synonyms: Gli3^P1-4
• Gene: Gli3 Location: Chr13:15638308-15904611 bp, + strand Genetic Position: Chr13, 5.43 cM, cytoband A2
• Alliance: Gli3^tm2Blnw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:121609
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted
• Mutation: Insertion
• Mutation details: Genomic sequence including residues 846-914 were replaced with the corresponding human cDNA containing S to A mutations at the first four PKA sites. A floxed neo included in the vector was removed via cre mediated recombination. (J:121609)

Expression

In Mice Carrying this Mutation:	38 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gli3 Mutation: 81 strains or lines available

References

• Original: J:121609 Wang C, et al., The Shh-independent activator function of the full-length Gli3 protein and its role in vertebrate limb digit patterning. Dev Biol. 2007 May 15;305(2):460-9
• All: 3 reference(s)