Rbbp6^tm1Xya
Targeted Allele Detail

Summary

• Symbol: Rbbp6^tm1Xya
• Name: retinoblastoma binding protein 6, ubiquitin ligase; targeted mutation 1, Xiao Yang
• MGI ID: MGI:3711066
• Synonyms: Pact^-
• Gene: Rbbp6 Location: Chr7:122568980-122601780 bp, + strand Genetic Position: Chr7, 67.42 cM, cytoband F3
• Alliance: Rbbp6^tm1Xya page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:121586
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• The two exons comprising the Trp53 binding domain were replaced with a neo cassette. (J:121586)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rbbp6 Mutation: 57 strains or lines available

References

• Original: J:121586 Li L, et al., PACT is a negative regulator of p53 and essential for cell growth and embryonic development. Proc Natl Acad Sci U S A. 2007 May 8;104(19):7951-6
• All: 1 reference(s)