Fbxo2^tm1Hlp
Targeted Allele Detail

Summary

• Symbol: Fbxo2^tm1Hlp
• Name: F-box protein 2; targeted mutation 1, Henry L Paulson
• MGI ID: MGI:3711101
• Synonyms: Fbxo2^-
• Gene: Fbxo2 Location: Chr4:148245078-148250881 bp, + strand Genetic Position: Chr4, 78.68 cM
• Alliance: Fbxo2^tm1Hlp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:121568
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed neo cassette replaced exons 1-5 of the gene. Western blot confirmed absence of protein in brain and cochlea of mutants. (J:121568)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fbxo2 Mutation: 21 strains or lines available

References

• Original: J:121568 Nelson RF, et al., Selective cochlear degeneration in mice lacking the F-box protein, Fbx2, a glycoprotein-specific ubiquitin ligase subunit. J Neurosci. 2007 May 9;27(19):5163-71
• All: 4 reference(s)