Dmrtc2^tm1.1Zark
Targeted Allele Detail

Summary

• Symbol: Dmrtc2^tm1.1Zark
• Name: doublesex and mab-3 related transcription factor like family C2; targeted mutation 1.1, David Zarkower
• MGI ID: MGI:3711103
• Synonyms: Dmrt7^flox
• Gene: Dmrtc2 Location: Chr7:24569482-24577076 bp, + strand Genetic Position: Chr7, 13.33 cM, cytoband A3
• Alliance: Dmrtc2^tm1.1Zark page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:121537
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Crossing Dmrtc2^tm1Zark mice with mice expressing Flpe recombinase in the germiline resulted in the excision of the neo, leaving exons 2 and 3 flanked by loxP sites. (J:121537)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Dmrtc2 Mutation: 13 strains or lines available

References

• Original: J:121537 Kim S, et al., A mammal-specific Doublesex homolog associates with male sex chromatin and is required for male meiosis. PLoS Genet. 2007 Apr 20;3(4):e62
• All: 1 reference(s)