Dmrtc2^tm1.2Zark
Targeted Allele Detail

Summary

• Symbol: Dmrtc2^tm1.2Zark
• Name: doublesex and mab-3 related transcription factor like family C2; targeted mutation 1.2, David Zarkower
• MGI ID: MGI:3711104
• Synonyms: Dmrt7^-
• Gene: Dmrtc2 Location: Chr7:24569482-24577076 bp, + strand Genetic Position: Chr7, 13.33 cM, cytoband A3
• Alliance: Dmrtc2^tm1.2Zark page

Germ cell apoptosis in Dmrtc2^tm1.2Zark/Dmrtc2^tm1.2Zark mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:121537
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Crossing Dmrtc2^tm1Zark mice with mice expressing cre in the germline resulted in the deletion of exons 2 and 3, as well as the frt-flanked neo. (J:121537)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dmrtc2 Mutation: 13 strains or lines available

References

• Original: J:121537 Kim S, et al., A mammal-specific Doublesex homolog associates with male sex chromatin and is required for male meiosis. PLoS Genet. 2007 Apr 20;3(4):e62
• All: 1 reference(s)